Your Health Markers: Functional vs Conventional Ranges in Inflammation & IBD

1. Conventional vs Functional Ranges

  • Conventional ranges are designed to detect active disease or severe inflammation. They often miss subtle imbalances.

  • Functional ranges are narrower and focus on optimal health, helping us identify early signs of inflammation before it triggers flare-ups.

💡 Example:

  • CRP (C-reactive protein)

    • Conventional: <10 mg/L = “normal”

    • Functional: <1 mg/L = optimal (anything above 1 can suggest low-grade, hidden inflammation).

2. Why Optimal Ranges Matter for Gut Health

  • You can experience IBD symptoms even when conventional labs appear “normal.”

  • Functional ranges highlight subtle inflammation that can drive fatigue, gut irritation, and flare risk.

  • Staying within optimal ranges supports remission, healing of the gut lining, and long-term resilience.

📊 Examples:

  • Calprotectin (stool test)

    • Conventional: <250 µg/g = “normal”

    • Functional: <50 µg/g = optimal for gut repair and reduced flare risk.

  • Vitamin D

    • Conventional sufficiency: >30 ng/mL

    • Functional: 50–80 ng/mL = optimal for calming the immune system and lowering inflammation.

3. Lifestyle Factors That Influence Inflammation

Your daily choices directly affect your lab markers and gut health:

  • Nutrition: Anti-inflammatory foods (omega-3s, colorful veggies, whole foods) help repair the gut and reduce flares. Highly processed foods, excess sugar, and alcohol can drive inflammation.

  • Stress & Mindset: Chronic stress increases cortisol, disrupts the gut lining, and worsens inflammation. Relaxation practices and nervous system support can lower flare frequency.

  • Sleep: Deep, restorative sleep helps regulate immune responses and repair tissue. Poor sleep raises inflammatory markers like CRP.

  • Environment: Medications (NSAIDs), toxins, smoking, and certain food sensitivities can trigger inflammation and worsen symptoms.

4. Smart Questions to Ask Your Healthcare Provider

  • “Am I in the optimal range for inflammation markers, not just the conventional one?”

  • “What do my CRP or calprotectin levels mean for my gut health today?”

  • “How do lifestyle factors—like diet, stress, and sleep—affect these markers?”

  • “Can we track my results over time to watch for trends instead of waiting for a flare?”

  • “Are there natural or integrative strategies that can help reduce inflammation and support remission?”

Bottom line: Functional medicine helps you move from ‘normal’ to optimal. For IBD and inflammatory conditions, this means calming the fire, protecting your gut lining, and restoring long-term vitality.

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